Image credit: Barth van Rossum. See also Article, Research Briefing
Our work focuses on mammalian cell engineering of next-generation molecular sensors, actuators, and genetic functions for molecular imaging and remote spatiotemporal control of cellular processes across multiple scales. We apply these biosynthetic devices to establish bidirectional communication with cellular circuits in organoids and preclinical model organisms to reverse-engineer cellular network function and aid future imaging-controlled regenerative and cell therapies.
References
- F. Sigmund et al. "Genetically encoded barcodes for correlative volume electron microscopy", Nature Biotechnology, 2023. Article, Research Briefing
- Emslander Q., Vogele, K., Braun, P., Stender, J., Willy, C., Joppich, M., Hammerl, J.A., Abele, M., Meng, C., Pichlmair, A., Ludwig, C., Bugert, J.J., Simmel, F., Westmeyer G.G., Cell Chemical Biology, 2022. DOI: 10.1016/j.chembiol.2022.06.003
- Dyka, M., Raffl, Phlairaharn, T., Greisle, T., Zivanic, M., Grosch, M., Drukker, M., Westmeyer G.G., “Intron-encoded cistronic transcripts for minimally-invasive monitoring of coding and non-coding RNAs." Nature Cell Biology, 2022; 24, 1666–1676. *equal contribution Abstract
- Truong, J, Phlairaharn, T, Eßwein, B, Gruber, C, Tümen, D., Baligács, E, Armbrust, N, Vaccaro, F.L, Lederer, E., Beck, E.M, Geilenkeuser, J, Göppert, S, Krumwiede, L, Grätz, C, Raffl, G, Schwarz, D, Zirngibl, M, Živanić, M, Beyer, M, Körner, J.D, Santl, T, Evsyukov, V, Strauß, T, Schwarz, S, Höglinger, G, Heutink, P, Doll. S, Conrad, M, Giesert, F, Wurst, W, Westmeyer, G.G: “Non-invasive and high-throughput interrogation of exon-specific isoform expression.” Nature Cell Biology, 2021; 23(6): 652–663. Abstract
- Sigmund F, Massner C, Erdmann P, Stelzl A, Rolbieski H, Fuchs H, de Angelis M H, Desai M, Bricault S, Jasanoff A, Ntziachristos V, Plitzko J, Westmeyer GG: "Bacterial encapsulins as orthogonal compartments for mammalian cell engineering". Nat Commun. 2018; 9: 1990. Abstract